Since appearing as recurring segment on the Animaniacs cartoon and their own eventual spin-off show, the sophisticated wit and charm of genetically altered lab mice Pinky and the Brain have captured the hearts of viewers around the world. In fact, I’d go so far as to say that the characters have earned their place among the echelon of other comedy duos such as Abbot and Costello or Laurel and Hardy. The same can be said for the voice actors themselves, Rob Paulsen and Maurice LaMarche respectively.

With the Animaniacs revival on Hulu, Pinky and the Brain have returned as well to resume their twilight campaign and prove their mousy worth by taking over the world. However, this reboot almost never came to be. Around the time serious discussions about reviving Animaniacs took place a few years, Paulsen revealed to his friends and colleagues that he was battling throat cancer. Since then Paulsen has made a full recovery but for a time there remained a very real possibility that his career may have come at an end. In which case, LaMarche and the rest of the original cast would have refused to reprise their roles without Paulsen.

We spoke with Paulsen and LaMarche about how their real life friendship transcended a mere working relationship voicing Pinky and the Brain.

Watch our exclusive interview below!

Animaniacs Season 2 premieres this Friday, November 5th on Hulu.

Hellloooo, season two! Hulu, Amblin Television and Warner Bros. Animation have joined forces once again to bring you “Animaniacs.” This Emmy® award-winning animated series—and one of Hulu’s all-time most talked about shows on social media—returns with 13 brand new episodes on Friday, November 5.

Yakko, Wakko and Dot return for an all-new season of this iconic, family-friendly series with something for everyone: pop culture parodies, musical showstoppers, takedowns of historical baddies…and even some important safety tips. Join the Warners and Pinky and the Brain as they wreak havoc everywhere they go, from the Warner Bros. lot to an international beauty pageant and all the way into outer space. And keep an eye out for season one favorites Starbox & Cindy, as well as some rejected Animaniacs characters that were left on the cutting room floor.