Therefore the very first thing the artist must do upon a approaching a page is pin down the balloons. In fact I go so far as to do all of the lettering first, because in addition to the above, lettering will take much less reduction in size than a picture, therefore it is essential to give the lettering priority. When I am certain that the lettering follows reading-logic, only then do I start drawing. Each balloon should follow clearly from the one before it no matter where the panel borders are placed.
Of course, that’s easy for Eddie, easily one of the most natural and intuitive cartoonists ever, to say. Much more of interest in the link.