England is gone, replaced by a new World Tree, promising to end this world and replace it with something new. Hellboy speaks with a spirit that may be his friend Alice, but who also appears to be something more. She delivers a prophecy of doom and beauty to Hellboy, who awakens, and finds himself in Hell once more. And then things start to get weird.
The Hellboy universe expands once more with the re-introduction of Frankenstein to Mignola’s ever expanding cast.